aja8888
Moderator Emeritus
Simple - when the risk of the downside is offset by the expected gain on the upside.
No different from just about everything we do every day. Should I drive to town to get groceries - the downside is I might get killed in a car accident. Should I eat the groceries - the downside is they may contain salmonella, or e-coli, or some other harmful thing. Should I get out of bed.... and so on.
-ERD50
It's not worth it when one of the downside effects is possibly death.