I reorganized my pants pockets ... seriously, I'm not kidding.
Guys don't usually have those mammoth bottomless purses.
Front right pocket: tissues (for allergies), reading glasses in carry tube, keys
Right little slip pocket: chapstick
Front left pocket: new tri-fold wallet with valuables, cell phone, pen
Back left pocket: comb, thin wallet with items that I can easily replace
Back right pocket: not used at present
The tri-fold wallet helps a lot and it is thin without any contents.
When on vacation, I have REI cargo pants for some possible extra items.