I actually went an unusual route. We have radiant slab in our walkout basement (with 2 bedrooms, bath, laundry/utility and family room) and hot water baseboard on the main floor (great room and master bedroom suite).
"Furnaces" were hugely expensive so I went with an on-demand hot water heater that powers the radiant heat, the hot water baseboard and provides for our domestic hot water. We got a Takagi but my plumbing guy says they are using something different/better in new installs. The on-demand hot water heater cost about 20% of what a furnace would have cost (~$1,800 IIRC) so I'm figuring that even if it doesn't last as long as a furnace and I have to buy 3 or 4 in the same timespan that a furnace would last that I am ahead of the game. A calculated risk on my part.
LBYM solution that has worked well for us for 3 seasons and still going strong.