Depends on whether they are entirely habituated to people or not. The ones in my suburban neighborhood are pretty shy when people are around and if you see them they disappear fast. They do claim a number of cats running loose and the occasional little rat/dog on a leash/running loose. If this is the situation by you, make some noise if they are around and they will split. Don't leave trash cans or other sources of an easy meal around. If you have small pets, keep them indoors. I don't spend a lot of time worrying about the two hound dogs when they are in my fenced yard, but I would not let them off the leash.
If your coyotes are not afraid of people, you have a bigger problem. Make noise, throw rocks at them when you see them and in general make it clear they are not welcome. They may eventually regain a healthy fear of humans. Keep some pepper spray or a handgun with you when you frequent areas they may show up. Watch your pets and any kids that might be around.
Where are you? In the West coyotes are still coyotes and average 35 pounds or so. They usually are not very bold. In the East they are heavily hybridized with dogs and wolves, are a lot nastier, and can reach 75+ pounds. Before I escaped the People's Republic of New Jersey there were several cases where a coyote hybrid tried to drag a toddler out of someone's suburban yard.