Originally Posted by bld999
Type 1 diabetes has always been identified as an autoimmune disease AFAIK.
Type 2 is not autoimmune.
Is there some newer info?
I think the science is ongoing and the evidence is not yet clear, but the research has been identifying an autoimmune component for a number of years. It's probably less accurate to break Diabetes down into different diseases (one autoimmune and another metabolic), and more accurate to identify a continuum where there are both autoimmune and metabolic elements present. A well known example would be LADA, which is referred to by some people as Type 1.5 Diabetes - it's more of an autoimmune disease, but it does have features of the T2DM metabolic disease.
A 2002 study in England found that 10-15% of T2DM patients exhibited evidence of Islet cell autoimmunity. There are more recent studies supporting the assumption that T2DM also encompasses autoimmune aspects based on the presence of circulating autoantibodies against β cells and self-reactive T cells. This from 2011 studies of humans in Canada:
“We were able to show that people with insulin resistance make antibodies to a select group of their own proteins. In contrast, equally overweight people who are not insulin-resistant do not express these antibodies. It’s highly suggestive that your body targets its own proteins as part of the development of insulin resistance...It really links the concept of insulin resistance to autoimmunity.