Esomeprazole = omeprazole, therapeutically. There are always individual issues that can override that generality ...
Just out of curiosity, what rough percentage would you say would find Prilosec doesn't take care of the problem but Nexium would?
Like most everybody else who has commented, my first thought was AZ is just trying to keep the big bucks coming in with the Nexium molecule. I would just grab some OTC Prilosec and rock on. But I ran across forums with zillions of comments from people who expressed a very clear preference for one drug, because the other "sucked" (pardon the technical phrase). OP said that nothing else was working for his DW.
Or are there that many people out there that are just totally confused on the meds?
As usual I am impressed with the knowledge on this board! Not to highjack this thread, but: I have a self developed approach of a daily Prilosec (supper time) and if I've been "bad" (often am) I also take a 150 Zantec as I go to bed. This usually lets me get through the night (only time I really suffer is night). Does this make medical/chemical sense to anyone?
I don't know. But I had a serious GERD incident when I was in my 30's (thought I was having a heart attack and drove to the ER) that I briefly used Prilosec for. There are triggers for GERD that can be avoided, I found that not eating late, not over indulging in rich foods, coffee, alcohol and cigarettes did wonders. I would take an occasional Zantec if I had hit on too many triggers, but I mostly resolved the GERD problem with diet and lifestyle modification.
When I was in my 40's, I found, by accident, that a low-carb diet
completely eliminated any digestive problems. No GERD, no indigestion, no problems at all.
Since I ER'ed I've turned into a carbaholic and I've recently developed symptoms again. I bought some Prilosec a couple of months ago. Currently, I'm girding (hah, a pun) myself to go back to eating low carb. Not Atkins, but less refined foods, sugars, and definitely no/reduced "white" stuff (potatoes, rice and bread). It's going to be tough, wife and kids can all eat anything they want without gaining an ounce or having any problems, and all three of them would eat pasta at every meal. I am tempted too often by pasta, rice and potatoes that wind up on the dinner table.