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Plavix vs generic
Old 01-15-2012, 07:49 PM   #1
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Plavix vs generic

Since my cardiac bypass in 2004, I have been prescribed the drug Plavix. It has gotten very expensive in the last two years through my mail order prescription plan. I get a 90 day supply for about $180 copay. About a year ago I thought I'd try a Canadian pharmacy that does a lot of business in this area. I can get the generic equivalent for $85 per 90 day supply.

The generic is mfg by Cipla pharmacy in India and from what I was able to find out, is approved by our FDA. The last order is still by Cipla but now comes from Vanuatu in the south pacific. I am feeling more aches and pains and wonder if I should be concerned about this change in the manufacturing facilities. I'm calling my doctor tomorrow for another prescription which I will fax to my mail order pharmacy and get another supply of the real thing (Plavix).

Was wondering if anyone has experienced a similar reaction to a generic version of a medication? I am going to try to contact the FDA and check this out. Any ideas?

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Old 01-15-2012, 10:04 PM   #2
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I'm no expert, and so far (knock on wood, could change at any second) I don't take drugs. But from the experiences of my relatives, I would say you should check with your doctor as well as the FDA. Here are a couple of links I found illuminating (and I hope someone with medical training will jump in and inform us all):

Worried about generics?

"The FDA inspects the nation's approximately 3,000 domestic drug plants about once every two and a half years, according to a U.S. Government Accountability Office report published in September 2008. But the agency inspects only about 8 percent of foreign facilities in a given year, so that it would take more than 13 years to get to that group of plants, the GAO estimates. Overseas plants make ingredients for generic and brand-name drugs. An FDA spokeswoman says that the agency's recently opened offices in India and China will "over time allow greater access for FDA inspections." The FDA is beginning to collaborate with European countries and Australia to share inspection responsibilities."

Johns Hopkins: Prescription Drugs on safety of generic drugs: Johns Hopkins Health Alerts

"Health insurers love generic drugs, because they cost less money than branded versions -- on average, 30 percent less. But there are some instances when your doctor may not think it’s a good idea to switch to a generic drug. This is often the case for medications that have a narrow therapeutic range (NTR). When you take an NTR drug, the most effective dose with the fewest side effects lies in a narrow range between too little and too much. These are medications in which small changes in the dose and/or blood concentration could result in clinically important changes in drug efficacy or safety. Usually, these drugs require frequent adjustments in the dosage and the user needs to be monitored carefully, regardless of whether the drug is a brand-name or generic drug product."

So I personally would talk to my doctor as well as the FDA.
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