Neosporin contains neomycin, an antibiotic that frequently causes skin (topical) allergies. I never prescribe it. Polysporin is a similar ointment but without the neomycin.
I don't know what your specific problem is, but I have "cured" many skin "infections" by just stopping Neosporin. Just saying... worth asking your doc about that possibility.
San Francisco Area
ESR'd March 2010. FIRE'd January 2011.
As if you didn't know..If the above message contains medical content, it's NOT intended as advice, and may not be accurate, applicable or sufficient. Don't rely on it for any purpose. Consult your own doctor for all medical advice.