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Old 09-21-2014, 11:42 AM   #21
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The article conveniently does not differentiate Niacin from Niaspan. Yeah Tredaptive is the main culprit as is Niaspan - both extended release. They cite no evidence for harm from immediate relese Nicain, which is what Niacin is.

As is usual madia hype crap blaming the base rather than the junk it is mixed with.

Edit add: By the way Niacin is OTC, no huge pharma profits to made, unless mixed with some crap that will kill you, unless properly dosed, by a doctor, who bases the dosing on pharma's calculations.
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Old 09-21-2014, 12:16 PM   #22
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What concerns me are specialists who recommend procedures at the end of life.
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Old 09-21-2014, 03:29 PM   #23
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Originally Posted by ls99 View Post
The article conveniently does not differentiate Niacin from Niaspan. Yeah Tredaptive is the main culprit as is Niaspan - both extended release. They cite no evidence for harm from immediate relese Nicain, which is what Niacin is.

As is usual madia hype crap blaming the base rather than the junk it is mixed with.

Edit add: By the way Niacin is OTC, no huge pharma profits to made, unless mixed with some crap that will kill you, unless properly dosed, by a doctor, who bases the dosing on pharma's calculations.
As the article states, the extended release forms of niacin were developed to minimize side-effects from the base (immediate release) form. For most drugs, likely including niacin, high (peak) blood levels are generally associated with the worst side-effects.

Info on possible side-effects of niacin (immediate and extended release) can be found here-
NIACIN AND NIACINAMIDE VITAMIN B3: Uses, Side Effects, Interactions and Warnings - WebMD

And here-
Niacin Side Effects in Detail - Drugs.com

And here-
Niacin can boost 'good' cholesterol - Mayo Clinic

BTW- These articles are all referring to HIGH dose niacin used to lower blood cholesterol (500 milligrams to 3+ grams/day), not nutritional (vitamin) doses (~15milligrams/day).
Niacin: MedlinePlus Medical Encyclopedia
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Old 09-21-2014, 06:04 PM   #24
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This could get into a really long and entertaining story:

At the risk of pointing out the convenient mislabeling, comingling and confusion thus created here is the top line from your shown link of Drugs.com:

"Niacin

Pronunciation
Generic Name: niacin (nicotinic acid) (NYE a sin (NIK oh TIN ik AS id))
Brand Names: B-3-50, B3-500-Gr, Niacin SR, Niacor, Niaspan ER, Slo-Niacin "


Do notice that anything that modifies the name NIacin is not unadultareted Niacin, it is stuff to modify the flushing effect with some added crap, the flushing and itching which is somewhat annoying to people, but never shown to be harmful.


Disclaimer: I'm no doc, don't play one on TV, do take Niacin, was harmed by Niaspan. Fired the doc in writing who prescribed Niaspan and Bextra, with a copy of the firing letter to the FDA and a copy to the medical board of the state.

The prescribing doc upon hearing of adverse reactions refused to see me on short notice, , said schedule an appointmet. Walked into a doc in the box, where the doc in excrutiating detail eplained the problem(s), $200 please at the counter, the causes, and served up a fix. Thus I do have some understanding of the differences.

Shortly thereafter I learned to read very carefully, with feeling and dictionaries at hand, and through undertanding all the info on drugs before taking them. Yeah I often mis-spell niacin. The noted events were some 15 or more years ago, took me a while to smarten up.

Happy days!
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Old 09-21-2014, 07:29 PM   #25
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Sorry to hear 'bout your bad experience with Niaspan, and the dust up with your old doc. Agree with your point that individuals may react differently to different forms of the same basic drug. And that it is good to be informed about your medications- and any proposed treatments for that matter.
But "old-style" niacin itself (in cholesterol-lowering doses) is clearly not risk free. Beyond itching & flushing (which can seriously lower blood pressure in some folks), liver problems (including jaundice) with niacin was reported many years before the extended release forms became available.
Niacin
TOXNET
Brief web search even showed a report of niacin-associated jaundice from 1959.
TOXNET
That does not mean that all folks taking plain niacin get liver problems, just that it is something to be aware of.

Best of health to you!
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Old 09-22-2014, 07:53 AM   #26
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Well, based on what I've read here, combined with what I've read on the importance of having good HDL numbers, and seeing my HDL go up close to 100% when I started taking (plain old fast release flush inducing OTC) niacin, I'm sticking with it. I can pretty much guarantee that whatever damage I might do to my liver with niacin is dwarfed by certain other activities I enjoy. Plus, my doctor checks my liver enzymes regularly, and so far so good.

I don't necessarily buy into having statins that lower cholesterol result in longer life expectancy. But I've read enough to believe that having high HDL numbers really does decrease your chance of heart disease. And since I was unlucky enough to have a genetic predisposition to having very low HDL I think it's great that I can find a product that actually makes a measurable improvement. I don't know if artificially increasing HDL has the same result as having a naturally high HDL, but I'll give it a chance. Especially since my brother died of a heart attack at age 42.

As far as seriously lowering BP, that's an additional bonus in my case.
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Old 09-22-2014, 09:14 AM   #27
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I've read enough to believe that having high HDL numbers really does decrease your chance of heart disease.
I agree. My HDL was always good, and since I've been on a LCHF diet it has been great.
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Old 09-22-2014, 09:29 AM   #28
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I agree. My HDL was always good, and since I've been on a LCHF diet it has been great.
My HDL has always been good too, under moderated carb. When I went serious LCHF, HDL increased and LDL's increased too. But my ratios are still very good.

Concerning LCHF and being a brewer...I participated in a study which required an online food diary where they asked percent of macro nutrients. They asked where I got the majority of my carb calories, and gave examples (bread, sweets, soda). You know what I answered!
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