We have been using AirBNB/VRBO for about 20 years. What we have found is:
1) Only go with listings that have lots of comments. Be aware that the owner will review you as well as you reviewing the owner after the rental.
2) Payment and cancellation policy are on each listing and set by the owner, so they can be pretty random.
3) Treat the rental like you would if a friend was lending you their place. These are not hotels, they are peoples homes and investments. Generally they will be quite helpful but you can't treat them like a concierge. If you leave the place a mess, the review they give you may keep you from being able to rent a different place in the future.
4) Once you are in the place, read the rules sheet that they normally have in the place. There may be things like, please turn the dishwasher on before you leave, or put the towels in the wash before you leave, etc.
We enjoy using vacation rentals as the prices are better normally and you get a full kitchen. Hotels get old real fast.