Not the entire length, but we went from Fort Stewart, FL to Moorehead City, NC in 2012. We took about 3 weeks but we weren't in a hurry, doing about 50 miles a day, anchoring mostly, and parking in a marina and exploring when we got to an interesting town.
My favorite spot was probably the very remote swamps of Georgia because of the solitude we experienced and stunning beauty.
Check Active Captain each morning before setting out and mark any potential shoaling or other hazards. Keep a flip chart on your lap for reference, don't rely on just the GPS screen, and honor the channel markers over the GPS magenta line.
Also beware that the ICW traffic can get halted for many hours in spots around military bases when exercises are taking place. This happened to us and we almost missed the high tide we needed to get over a shoal!
PM me if you gave any specific questions.
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