Did it once out of necessity, Riyadh to Toronto via NYC in 1988. We had two cats in their boxes in the cabin, (since we were upgraded to First Class and then Business Class).....gave the cats tranqs before the flights......one of them came out of it over the Atlantic, freaked out and almost pulled the small blanket covering the box into the box through the grill.
I'd suggest you wouldn't be doing them, or you, any favors by putting them through that in two directions, especially if they're put in the hold where animals have died or escaped.
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"Exit, pursued by a bear."
The Winter's Tale, William Shakespeare
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