Yes. We have a number of vacation rentals. Whether we use VRBO/Homeaway depends on the market. We have 4 units at a beach location where renters normally contact local realtors for vacation rentals so we list with a realtor there. Another of our rentals is a home we bought in 2010 in a popular tourist location in the northeast. We exclusively rent the place through VRBO/Homeaway. It has worked very well for us. We have chosen not to use Airbnb. To me it helps a lot if your place is different and not run of the mill. Our place is architecturally different with a great view. Not sure we would do well if our place was the same as 20 others.
Keep in mind that you live and die by the Reviews. It is very important that you do what you can to obtain good ones. We have had more than 500 renters over the past three years and have never had a problem. We have a three day minimum but have rented for 2 months at a time. It varies. We have met some very interesting people from all over the world. It is important to be diligent, have a great cleaning crew, a good occupancy agreement and enjoy dealing with people. The return for us renting this way is more than double what an annual rental would bring, even taking into account the increased expenses (i.e. cleaning, utilities, cable, etc....) If you have further questions you can PM me. Tell me you did so publicly so I will look.