The average rent for a two bedroom apartment in San Francisco is $4,487 a month, median home price over $1.1M. I really like it here in the Bay Area, but from looking online even London and Paris seem cheaper these days, at least for comparable housing, and smaller cities look like real bargains.
If we have to pay ~$30K a year again just for health insurance premiums here (if we can even get insurance with actual full coverage post-ACA), I think that might be our tipping point for moving, at least until Medicare age (also have to wait and see what happens with that program).