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Keto diet & more production of SHBG?
Old 04-30-2020, 01:19 PM   #1
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Join Date: Dec 2010
Posts: 428
Keto diet & more production of SHBG?

Sex Hormone Binding Globulin (SHBG) is the major thing that "binds" Testosterone. And most of it is bound.

The liver makes SHBG.

So I want to know if it makes MORE SHBG when it processes more fatty acids. If so, then a Keto Diet would raise your SHBG.

My very ancient understanding was that SHBG caused T to be sequestered in fat cells. Hence reducing bodyfat improves T levels. Maybe that's not true, or so simple.

Discussion of all the binding molecules & difficulties in getting accurate & reproducible tests of T levels, and how different binding molecules act.

A Reappraisal of Testosterone's Binding in Circulation: Physiological and
Clinical Implications

Anna L. Goldman, MD, Shalender Bhasin, MB, BS, Frederick C.W. Wu, MD, Meenakshi Krishna, Alvin M. Matsumoto, MD, Ravi Jasuja, PhD
Endocrine Reviews
Endocrine Society
Submitted: January 29, 2017
Accepted: June 23, 2017
First Online: June 2 , 2017
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