Many years ago a doc prescribed nisapan based on then available info on it and my personal parameters then. After researching the stuff, discovered slow release niacin is really bad for the body. In fact it stresses the liver as I remember. Can't remember all the gory details.
One must always read the "mechanism of action" and all the other disclosures of all meds prescribed, and must understand each word therein in the most restrictive context. Sometimes a magnifier is needed to find the really gory details. Skip the reading at you peril. It is written by lawyers and chemists and FDA reviewed, it is virtually all CYA. Especially black box disclosures. I refused the stuff. I have been taking Niacin for long time.
Recent doc visit, he said: we now practice evidence based medicine, and the the lowering of numbers does not change longevity outcome. As a joke, I said I am shocked, you mean previously the evidence did not matter? We are on good terms, he gave wry smile.
IIRC there has been meta-analyses of the famed and oft quoted Framingham study, much of which has been intentionally misinterpreted by the drug companies to enhance sales of crap. My understanding is that cholesterol is an effect, not a cause. Inflammatory functions are causes. My body, my choices as to what I put in it.
By the way I will continue to take niacin, it is cheap, don't care that the lower "numbers" do not change date of death. A disliked effect the niacin flush, I think is a benefit and good thing. It dilates small blood vessels in the skin, thus gives a kind quick flush to the skin. And thus helps having supple skin. YMMV.
As an aside I was an early vicim of Bextra, and various famous cholesterol meds. Having survived the experiments, I now do a lot of reading before accepting any med. even if I accept it, it is only for very short term. As I get older I may need meds, but they will be exhaustively researched. There may come a time when there will be choice to made. Put up with nasty side effects or exit.