Similar situation here. DD graduated from college, has a great career that pays well and has good long term prospects and is a go-getter. DS is a really nice kid and I love him dearly but has been like a deer in the headlights in terms of his life's work - while we have seen progress over the last year in that he successfully completed some training, got licensed, got a full-time job with benefits and moved out on his own, he still lacks ambition.
I've noticed for many of my peers' families, the girls seem to be lighting up the world while the guys are doing ok at best in terms of education, careers, initiative, etc. I kid with some of my peers that I don't understand why women aren't running the world right now (or soon will be).