We've recently used miles to Rome & Madrid. Barclays AA card (red/black colored) has a decent bonus. DW does the air points game, so I don't know specifics, but it makes a huge difference on timing of the flight. If I recall, it was 65k points for direct, r/t from DFW to Rome in September, last year. The cost of a cash ticket was closer to $1k, going to $3k closer to the date.
AA has quite a few options for partner airlines around the world, so it works for us. Them based in Dallas probably helps too.