Yes, but this is a bit confusing because we started with "she really can't predict" and now we're at "less than the standard deduction".
For this year, even if she's sure she won't make much, I would highly recommend that she go ahead and figure the estimates each quarter using the IRS forms rather than just doing a divide-by-four approach. This is an excellent way to learn how the taxation of self-employment income works. It might take an hour or so the first time, but that will demonstrate where her business record keeping can be improved to make the next time easier. Then the final January calculation should get her very close to her actual tax return. Getting the record keeping process established and fine tuned in the first year will make everything much easier going forward, and if her business grows to the point where she engages a bookkeeper and/or tax preparer, being able to hand off information in a usable format will save her money.
After this year she could do the "prior year taxes divided by four" method to reach the safe harbor.