I lost count of the number of times I have used Efudex over the past 25+ years. Mine was mainly on my scalp. By the 3rd day the burning was harsh like I had been burned with boiling oil and I still had 3 weeks or more to go. Then a few years ago the dermatologist suggested a blue light treatment where a chemical was applied, then a 2.5-3 hour wait, then I sat under a blue light for 17 minutes. By the end of the first minute it was getting painful but she had a cold air blower I could direct at my scalp that helped a little. After 17 minutes it was over and the residual discomfort only lasted about 3 days and it was done. Much better. I also use a thin Fluorouracil liquid between blue light treatments that is not as bad as the Efudex cream.
I usually have to have something done every 6 months. If not a treatment that I mentioned then it would be liquid nitrogen. It is getting better than it has been.