We drove FL-MI at the end of April, I also had an overnight business trip that put me in a hotel. (Yeah, I'm still w*rking occasionally, we'll see how long that lasts.)
We opted to drive 1100 miles straight through. We made 3 stops for fuel, I used a phone app for "loves" truck stops that showed me where I could find them, and confirm they were open as well as fuel price. Restrooms were open at all of the fuel stops we made. Those were the only bathroom breaks we took, but as others have mentioned, we were prepared in the event that we couldn't find an open rest area. We brought our own food and drinks, which kept us away from others and let us keep rolling. Still had a guy try to hit me up for money at one of the stops...
On my business trip, I stayed in a hotel near the airport that generally caters to business travelers. There weren't many guests. They did have the restaurant open, but since my trip was short, I opted to do a bit of a "hotel camp out" and brought what I'd need to eat, instant coffee, etc. This is no big deal to me since I still go camping (in a tent) sometimes.
There WAS a bit of a change to the room--obviously every place is a little different, but it bears mentioning.
--At check in, I got a little ziplock bag of all the goodies that are normally out by the sink (soap, shampoo..).
--The TV remote was in a zip lock bag.
--There was no hair dryer in the room
--Also no coffee maker (I just used hot tap water to "brew" instant coffee. Barbaric, no?)
--None of the normal promotional brochures that are normally laid out over the desk and night stands.
Although you didn't ask specifically about it, a few comments on my experience flying one leg to and from the biz trip:
--Easy drive to and from the airport, little traffic
--Got a great parking spot
--No line at TSA (I checked a bag since I was carrying some food)
--Both flights had nobody in the middle seats. (I think Delta is doing this till the end of June)
--Everyone wore masks
--The people who cleaned the planes after the previous flight had some kind of fogging machine to also disinfect it.
--On the first leg, the agent took time to move a few of us around so we could be further apart. She asked us first, which was very considerate.
--On the way back, all the available seats were taken (middle seats still empty though). I was afforded the opportunity to board fairly early. In retrospect, I would have kept more distance from people if I had waited, since I got on, sat in an aisle seat and then most of the other passengers walked by me.
--The other passengers all seemed to try to keep some "social distance" on the way in, but when we got to the arrival gate and the seat belt sign went off, probably 75% of them got up, grabbed their bags and packed the aisle. Old habits die hard, I guess.
HTH...