I worked advanced aircraft vehicles for my career. The reusable shuttle had an expected cost and operational advantage over the single-use rocket-and-capsule systems of the 60s and 70s. The much lower than expected usage rate of the shuttle means that the whole infrastructure cost is divided by fewer launches and so it costs an arm and a leg for each pound that gets to orbit. Additionally, the original shuttles are getting older just sitting mainly on the ground; any vehicle gets less reliable as it is not used.
Maybe manned space exploration needs to be rethought, maybe new vehicles need to be designed and built, or maybe other approaches to the shuttle for getting people and equipment out there. Who knows what would come from a fresh look now 35 years after the original shuttle considerations.
One of the most intriguing ideas is the space elevator - just google space elevator for yourself - this concept apears to have the potential to deliver a payload to space at a very, very small fraction of the costs/pound of the shuttle. Nice to think about way-out ideas that just may work. The first country to do it would have a significant advantage over all others.
JohnP