We travel a lot. Generally try to stay in what I hope are lower-risk family run B&Bs or small hotels. Still, I diligently rip bed linens off, lift mattresses, and use a flashlight to check behind headboards and in bedside tables.
Keep all clothes in the large zip lock bags (bought online) they are packed in. Also keep pajamas and other bed-stuff in a separate plastic bag as we move from place to place.
Use lightweight collapsible luggage with minimal inserts that I can hang high in a hotel closet then vacuum and wash in the tub once home. Backpacks, if used, can go to a commercial laundry for drying. After returning, bag odd items (electronics, shoes) for a bit and dry clothes in high heat.
We had one scare where I found a series of mysterious bites after returning from Guatemala. Although there was reason to think they were from outside plant mites that could have found their way into to some bedding placed by the door I didn't want to play the odds. Spent $150 on a bedbug dog to check our place. We're in a condo and were about to leave for a month-long trip. Had visions of blood-hungry bugs deprived of us as a meal departing to latch onto our next-door neighbor. Obviously, this is a bit obsessive
but being in a condo my main concern is actually not bringing them home but becoming the source of a condo-to-condo migration - particularly to neighbors who wouldn't commit to the work involved to eradicate.
Too, we sometimes end trips with visits to friends.
Although initially puzzled I don't drag our luggage into their guest room, here I earn *lots* of guest brownie points ... Doing this is more appreciated than bringing wine.
Unfortunately I now have a teen daughter who fears to travel to New York City on an upcoming class trip.
I tell her not to worry. She and her stuff will be met at the front door and get all nicely sanitized. Not a problem ... go and enjoy.