They seem meant for travel, so there's the added challenge of finding a place in a hotel room. Maybe a pipe under a sink, if it is exposed? I suppose a drawer handle would be a deterrent since they've have to smash the drawer or lug around something obviously not right to have. A closet rod might be screwed in the wall tight enough to be a challenge.
Maybe you use it as a decoy, with nothing of value in it, and your valuables hidden elsewhere, but you're still out the $100 for the bag itself. Make a cheap decoy bag, maybe.
I don't leave much of value in a hotel room. What I worry most about is my laptop, which is too big for that bag and not so easy to hide.
For my house, I just try to have it more secure than average with Ring cameras, lighting, etc. Many houses on my street and community are 2nd homes, often vacant, so they are easier targets. And in general thieves don't find too much of value in 2nd homes, so we rarely get break-ins.