Yes.
The "beauty" of derivatives is that they are not bound by any physical constraint. In order to create a Residential Mortgage Backed Security (RMBS) I need a pool of residential mortgages. So the size of the RMBS market is constrained by the size of the mortgage market. But once I have one RMBS security outstanding I can create as many "synthetic" RMBS securities as the market will bear, all of which use the same pool of assets as a reference point (and perversely enough, the "raw material" for the synthetic RMBS are the other side of CDS contracts from people who want to bet against the original RMBS. Neat huh?)
These synthetic transactions have the effect of magnifying the loss potential of a single default. So while in the real world, only the actual lenders lose money when a mortgage defaults, in the synthetic world all of those who own securities referencing that mortgage can lose too. So $1 lent can yield more than $1 in loses. Of course in the synthetic world someone else stands on the other side as a winner so gains and losses even out in aggregate . . . that is, of course, as long as the losing party stays solvent. Oops.
And there you have a recipe for cascading bankruptcy as defaulting "losers" wipe out the assets of the "winners".