Novavax - will be the 4th FDA authorized vaccine for the United States

[cyber888]

https://www.miamiherald.com/news/coronavirus/article262292122.html

The US FDA met yesterday and the FDA VRBAC committee approved Novavax on a vote of 21 (yes) and 0 (no) and 1 abstained.

It will be the first non-mRNA vaccine offered in the US, using a traditional protein-based adjuvant, similar to those used for several years for Hepatitis, etc. It has 91% efficacy and tested on several variants, with much less adverse side effects. Durability is also 6 months or longer.

After Israel did the 3rd and 4th Pfizer jab and saw some Covid cases after, they ordered Novavax. EU has ordered 100 million doses for Novavax.

https://www.pharmaceutical-technology.com/news/novavax-israel-vaccine-deal/

I'm getting this new vaccine.

 

[anethum]

The JnJ vaccine is not an mRNA vaccine, either.

While many traditional vaccines have adjuvants, the one used in Novavax is virtually identical to the adjuvant used in the Shingrix vaccine, which was the first human vaccine using the saponin-based (not "protein-based") adjuvant derived from the Chilean soapbark tree, Quillaja saponaria. That adjuvant is thought to be the reason for both the efficacy of the Shingrix vaccine as well as the higher-than-average adverse reactions to it. It's interesting that Novavax trials apparently found that side effects were generally mild. However, because I had a very severe reaction to my 1st Shingrix shot, my PCP was adament that I not get the 2nd Shingrix shot, and put in my electronic medical record that I'm "allergic" to Shingrix.

An interesting nearly 2 year old article about the saponin adjuvant in Novavax:
https://www.theatlantic.com/science...cies-may-hold-key-coronavirus-vaccine/616792/

I'm grateful that I've had 3 Pfizer shots and 1 Moderna shot. I will avoid the Novavax vaccine because of the reaction I had to Shingrix.

 

[Gumby]

The JnJ vaccine is not an mRNA vaccine, either.

While many traditional vaccines have adjuvants, the one used in Novavax is virtually identical to the adjuvant used in the Shingrix vaccine, which was the first human vaccine using the saponin-based (not "protein-based") adjuvant derived from the Chilean soapbark tree, Quillaja saponaria. That adjuvant is thought to be the reason for both the efficacy of the Shingrix vaccine as well as the higher-than-average adverse reactions to it. It's interesting that Novavax trials apparently found that side effects were generally mild. However, because I had a very severe reaction to my 1st Shingrix shot, my PCP was adament that I not get the 2nd Shingrix shot, and put in my electronic medical record that I'm "allergic" to Shingrix.

An interesting nearly 2 year old article about the saponin adjuvant in Novavax:
https://www.theatlantic.com/science...cies-may-hold-key-coronavirus-vaccine/616792/

I'm grateful that I've had 3 Pfizer shots and 1 Moderna shot. I will avoid the Novavax vaccine because of the reaction I had to Shingrix.

Thanks for that info. I had a strong reaction to the second Shingrix shot, so perhaps I'll want to avoid Novavax. Even so, it was only a day of discomfort, so I would get this new Covid vaccine if it were the only choice.

 

[Irishgirlyc58]

I believe it will also be free of polyethylene glycol usually referred to as PEGS.
This is good news for people who may be allergic to PEGS.
I was tested for this allergy due to my reaction to the Moderna vaccine.
Thankfully I’m not allergic since pegs are an ingredient in several life saving medications.

 

[cyber888]

I believe JNJ already stopped production of their vaccine. I read somewhere they did pause. So, only Novavax will be a non-mRNA vaccine.



https://www.webmd.com/vaccines/covi...xt=Feb.,critical vaccine for poorer countries.



CDC has documented several allergic reaction to the current mRNA vaccine, which left my DW with tinnitus, and my brother with permanent vision problems. We will never take another mRNA vaccine.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788157/

https://www.cdc.gov/mmwr/volumes/70/wr/mm7002e1.htm

The JnJ vaccine is not an mRNA vaccine, either.



While many traditional vaccines have adjuvants, the one used in Novavax is virtually identical to the adjuvant used in the Shingrix vaccine, which was the first human vaccine using the saponin-based (not "protein-based") adjuvant derived from the Chilean soapbark tree, Quillaja saponaria. That adjuvant is thought to be the reason for both the efficacy of the Shingrix vaccine as well as the higher-than-average adverse reactions to it. It's interesting that Novavax trials apparently found that side effects were generally mild. However, because I had a very severe reaction to my 1st Shingrix shot, my PCP was adament that I not get the 2nd Shingrix shot, and put in my electronic medical record that I'm "allergic" to Shingrix.



An interesting nearly 2 year old article about the saponin adjuvant in Novavax:

https://www.theatlantic.com/science...cies-may-hold-key-coronavirus-vaccine/616792/



I'm grateful that I've had 3 Pfizer shots and 1 Moderna shot. I will avoid the Novavax vaccine because of the reaction I had to Shingrix.

 

[cyber888]

I believe it will also be free of polyethylene glycol usually referred to as PEGS.
This is good news for people who may be allergic to PEGS.
I was tested for this allergy due to my reaction to the Moderna vaccine.
Thankfully I’m not allergic since pegs are an ingredient in several life saving medications.

Yes, my family has had allergic reaction to mRNA vaccines, so now we will be going with Novavax.

 

[Irishgirlyc58]

Yes, my family has had allergic reaction to mRNA vaccines, so now we will be going with Novavax.

I’m glad that it’s finally going to be an option for you and your family.

 

[rodi]

This is good news for a friend of mine who did the trial in early 2020. He did the trial as a way of getting a vax, any vax, early. But then found it troublesome because he didn't have a vax card for travel and for dining out in LA. (He lives in San Diego, but has friends up there.)

He had no side effects, and has not caught covid.

 

[Alan]

My wife and I had Novavax as part of a blind mixed vaccine trial in April last year. It was our 2nd shot, and we had zero after effects which was something reported by the majority of the recipients. I would gladly have it again if it was offered as a booster this Fall.

 

[explanade]

NovaVax vaccine was designed in 2020.

Pfizer and Moderna are working on Omicron-targeted boosters for the fall.

NovaVax is also testing an Omicron-specific booster.

Problem is there's already a big difference between BA-1 and BA-5 and the Omicron boosters are designed for BA-1.

Still Moderna claims 8x antibody levels with the bivalent vaccine that they're working on. Why still have a vaccine with the original Wuhan variant target in 2022?

Because apparently, the original vaccinations created B-cells which are more responsive than the B-cells created by the BA-1 spike proteins. So they need both stimulated.

We did get vaccines within 1 year of the start of the pandemic, though many had warned it would take years to develop vaccines.

It may end up the case that next generation of covid vaccines which may regain some effectiveness against symptomatic infection won't be available for another couple of years, meaning 4 or more years after the start of the pandemic.

 

[sengsational]

I still want to know more about how they get the vaccine out of the moth larvae. I picture a huge blender, hehe!