A guitar setup is much more than restringing and tuning. You can find descriptions of a good setup online, such as:
https://www.electricherald.com/guitar-setup-pro-guide/
Basically, this entire process insures that a) every note at every fret plays at the correct pitch and b) the strings are as close as possible to the frets without buzzing while strumming. I have this done to almost every new guitar to insure that I'm starting properly.
Having the strings as close as possible to the frets greatly reduces the physical effort required to finger any given chord. This is critical since one of the biggest challenges in playing a chord (several notes played together) is properly holding down each note at the same time for what seems like an eternity while your fingers and hand screams out in pain!
The lower the "action", the closer the strings are to the frets and the easier it is to play the instrument. Of course, if the action is too long, the strings will buzz or hit against the frets where they shouldn't.
Generally speaking, the action or string height is set by filing the depth of the string grooves in the plastic nut (plastic piece that the strings pass over next to the tuning machines/pegs) and adjusting the saddle height (were the strings are anchored on the guitar body near the pickups). On a Fender Stat, the saddle is mechanically adjusted by turning a screw.
Once the initial setup is done, I've learned to change own strings. If I play daily, I like to change my acoustic guitar strings every month or two, when they sound stale. The electric guitar is much less picky, perhaps because the amp colors the sound so much. As for tuning, I tune every time I play, and maybe check a few times during a practice session. I prefer a "clip on" tuner that clamps on the head of the guitar near the tuners. Some phone apps like GuitarTuna w*rk well too and is a favorite with my young musician friends.
I normally sing and chord along with my acoustic, aka playing rhythm guitar. This thread has inspired me to revisit my Fender Tele as my rhythm accompaniment. I've got the same setup as you: my Mac for internet access, my Fender on a stand, and my beautiful Fender blues amp. Hours of enjoyment!