I live in south central PA, west of Harrisburg. I moved here from Silicon Valley in 1998 and did not look back. I spent one weekend house hunting and found the perfect house for us, so we took a chance and bought it. It worked out fine for us.
If you get away from the Philly suburbs and go a bit farther west, it is much more affordable. I live in the greater Harrisburg area. Hershey is just east of that-world class medical care, and we are also accessible to Johns Hopkins and the many stellar hospitals in Philly. The faculty at Penn State Medical Center formed their own orchestra years ago. We have many community theaters, other music groups, and several colleges in the area, as well as lots of summer activities along the Susquehanna River. Minor league baseball in Harrisburg and York, HersheyPark, Gettysburg. Good hiking and walking areas. I'm west of Harrisburg and less than 5 miles from the Appalachian trail. I can take the train to NYC or Philadelphia, and Baltimore and DC are a two hour or less drive.
One more thing about taxes: Property taxes are much lower in central PA than near Philly. PA doesn't tax retirement income as noted above. But they do have an inheritance tax. No tax for surviving spouse, 4.5% for adult children, 12% for siblings, 15% for the rest.
Another plus-it's not as cold as in Michigan, but we do get some snow.
I'd probably rent and explore to find out what situation works best for you.