Maybe I missed it, as I read the first few replies and then skimmed the rest, but how old is he, what job was he doing specifically, what is his degree in, and how long ago did he graduate?
OP, I know you mentioned poor grades in one of your posts, but if he's had a few jobs since graduating, grades may not matter much, if at all, just make sure his resume doesn't highlight bad grades. His work experience then speaks for itself, and then his degree is his degree, whether he graduated with a 2.0 or a 4.0... and I know this depends on his field, time since graduation, work history, etc.
I know others have mentioned waiting to start the job search. Unemployment compensation is probably going to be pennies, depending on what his salary/wage was, so I wouldn't suggest he take his time. He should try and find work quickly. There's nothing to say he can't still look for new employment if he finds a job he's not thrilled with, but will still pay the bills. It drives me crazy hearing stories of people being laid off for months at a time that would only take 'fill in the blank' jobs while sucking their savings dry. If you can find employment that pays more than unemployment, jump on it, and continue the job search.
Is he in a deadend career field? Would it make more sense to pursue another career field? Even if it meant more schooling. If the dollars and cents make sense to spend the money now to make more money later, maybe this could be the kick in the balls he needs to get started.
As far as providing unsolicited advice, I guess that depends on your relationship with him and how he handles things. Personally, if I were in that situation, I wouldn't ever ask my family for advice. I'd be too proud to. But, if they gave me some, I wouldn't turn it down, and it may help me. Food for thought.