Oh my, where do I start....
If you like books and are in Portland to not spend an evening at Powell's would be a sin. W. Burnside at 10th.
www.powells.com
The yuppy neighborhoods (restaurants, bars, cutsie shops) are in the Pearl District and NW 23rd. That is not to say that you won't find great places elsewhere, but that is where the 'buzz' is. Portland has always been a 'dine out' town, restaurants come and go. For a guide: Best Places Portland: The Best Restaurants, Lodgings, and a Complete Guide to the City (Best Places Portland) (Paperback) Beer is to be savored:
http://www.realbeer.com/destinations/portlandoregon/breweries.php Here is a tip sheet I found on line that includes several of my favorite places bakeries and eating establishments (I like my pastries French, my bread sour):
http://www.extramsg.com/uploaded_misc/portland_tipsheet.html#bakeries
Oregon has no sales tax, shopping is a major sport. Prices are generally lower than Seattle. Home of Columbia Sportswear, Pendleton, Nike (factory store in N. Portland has prices comparable to the employee store), Adidas. Find a 'Made in Oregon' store to pick up a souvenir if you are short of time.
Jogger? Run through Washington Park. Walk through the NIKE campus, sneak a run on the berm.
The newest thing is the tram to OHSU.
http://www.portlandtram.org/
Oh yes, ride the MAX.
Enjoy your visit. I said VISIT!!!