One of the mistakes I made early in my early retirement was playing the game of trying to minimize my taxes as close to zero as possible. It then occurred to me that I was spending my taxable funds and I was increasing my RMD and taxes later. So I started pulling all my retirement expenses from my IRA and pulled extra out for ROTH conversion up to the tax rate I was willing to pay.
My Roth, from when I was working and conversion, is about a 1/3 of my total assets, which I figure would be our long term care funds if we need it. Early on I decided I didn't want to much in ROTH since I don't trust the government not to change the rules and end up double taxing the ROTH. If they decided to replace part or all of the income tax with a federal sales tax the ROTH would be effectively taxed when used.
I am using QCD for the charities we already support and the rest is just income to do with as we would income from any source, spend/invest. I do use the RMDs to rebalance my AA as much as possible on a month to month bases and then do additional rebalancing when I get to far off my AA.