OP said "I" rather than "we", so saying single tax brackets.
With $300K in IRAs and 50 years old, Roth conversions are probably a good idea as otherwise the IRA could grow pretty substantially before RMDs start.
If OP needs ACA insurance, then staying within 4 x Federal Poverty Level for the MAGI is essential to get a premium credit. That's $54,360 and includes everything from interest, dividends, Roth Conversions, odd jobs, short and long term capital gains, state tax refunds, and even things that are excluded from a regular AGI calculation are added in such as the non-taxable portion of SS benefits, tax exempt interest and excluded foreign income. For 2022, any ACA MAGI above causes an 8.5% premium credit reduction. Beyond this year, it is a cliff, go over $1 and you get no premium credit.
If no ACA is needed, the situation changes very slightly. The best target is probably an AGI below the top of the 0% LTCG bracket. That AGI target is the std deduction ($12,950) + $41,675 = $54,625. That AGI does not include non-taxable portion of SS benefits, tax exempt interest of excluded foreign income. If you do a few $ over this, the tax cost on the increment is steep, paying regular income tax of 12% on the extra $, plus pushing a $ of capital gains to be taxed at 15%, so 27% (until all the capital gains have been taxed)
Some folks leave a residual in their IRA as a reserve for long term care, as that would be mostly tax deductible. Some leave their IRA mostly alone to give it away as QCDs, starting at age 70.5.
In any plan, you have to consider all the factors, your SS benefit and claim age, any pension, expectations for tax law changes, state taxes, possible big expenses or life changes like moving, asset allocation and your expectation for market returns, the goal for your money (live comfortably, give to charity, give to heirs). So OP has some work to do.