If you can get a 95% effective vaccine and you are in the highest risk group, what are the chances tht you will go without a mask among Covid-ineffected people?
If you can get a 95% effective vaccine and you are in the highest risk group, what are the chances tht you will go without a mask among Covid-ineffected people?
Emphasis added.
I would say if I was that person, I would wear a mask, but I would also feel much better in the event I found myself in a group of unmasked folks without my own mask. Even a 1 in 20 chance of infection is not that great for highest risk people. Just my 2¢ based upon the very little I know.
Yes, thanks for your contribution! And I hope you have access to a vaccine soon!DW and I functionally unblinded our phase 2 Novavax trial today. We apparently beat the odds and are both in the control group based on negative results from the Assure rapid antibody test which has 99% specificity.
So no gym or indoor pickleball this winter. Looking forward to availability of the Pfizer or Moderns version.
Now AstraZeneca vaccine showing good efficacy. Not as high so far as first two. Uses different mechanism to deliver also. And can be stored with just refrigeration. Still a two shots system.
That also means while you are less likely to get sick, you can get infected and be infectious to other people.
The term I've heard for a vaccine that makes it so you can't infect someone else after the vaccine has trained your body to recognize it is a "sterilizing vaccine". No current Sars-CoV-2 vaccine claims to fall into this category. But in my thinking (warning, he's doing it again!), if your body recognizes some virus that enters your body and starts eliminating it right away, there won't be nearly as many virus particles created, and fewer particles to share on your exhales or within your shared 'bodily fluids'.That also means while you are less likely to get sick, you can get infected and be infectious to other people.
If the vaccine helps with herd immunity, it has to be doing something that keeps the virus from spreading at its normal rate.
I'll be the first to admit that I know nothing, but my understanding is that coronavirus immunity, whether natural or through a vaccine, is relatively short lived. On the order of 2-6 months and most certainly varies person to person.
If you can get a 95% effective vaccine and you are in the highest risk group, what are the chances tht you will go without a mask among Covid-ineffected people?
OK, then give it just to those of us past the reproductive stage in life.Also, given that this could potentially be the first mRNA vaccine approved for human use, we are not at all sure about the long-term impacts of messing with the DNA blueprints of the human genome. Scary stuff from where I sit.
If you can get a 95% effective vaccine and you are in the highest risk group, what are the chances tht you will go without a mask among Covid-ineffected people?
If you can get a 95% effective vaccine and you are in the highest risk group, what are the chances tht you will go without a mask among Covid-ineffected people?
Over in the UK Dr John Campbell explains how the Oxford vaccine works. The AstraZeneca one. The gist of it is that it will take several weeks from getting the shots until you get the full immune effect. But then it's 90% efficiency for this one too.
So after the first of two shots there is an approximately two months of waiting before life can go back to more normal. Is this slow build of immunity how the other two current vaccines work?
Weird results with the AstraZeneca with 1/2 dose / full dose. So far, I haven't heard why it was weird.
The results show 90% effectiveness, but only if the first dose was half of the normal dose. This part of the trial was in Brazil, so maybe they wanted to make "n" large, but didn't have enough vaccine? Somehow they gave 1/2 dose on the first shot. Then, a month later, they gave a second dose, this time full dose. It turns out that the Brazilians in the study did better than the other group in the UK, where it was two full doses. The p values were great (1 in 10,000), so it's not like this could have happened randomly. I wonder if the Brazilian population is different. I'm sure they are genetically different than the UK group (UK would probably tend to be more genetically diverse). Or it could be the strain in Brazil was different. It will be interesting to watch this play out.
Do vaccines prevent disease or infection?
The type of efficacy that's been reported for these trials is protective efficacy against disease — in other words, how well the vaccine protects people from getting sick.
Whether or not these vaccines prevent people from getting infected in the first place is a separate question, and not one researchers can answer just yet.
Dr Labzin said it's possible there were people in the trials who received the vaccine, got infected with COVID-19, but didn't develop any symptoms.
They wouldn't have been identified, nor included in interim analyses, because researchers were specifically looking at whether the vaccine stopped or reduced the severity of COVID-19 symptoms — not whether the vaccine prevented the virus from entering a person's body.
"That's going to take a lot more analysis of the data and a lot more time," Dr Labzin said.
Both Pfizer and Moderna have indicated that their vaccines appear to prevent both mild and severe forms of COVID-19.
Can a vaccinated person still spread the virus?
One of the reasons it's important to find out whether coronavirus vaccines prevent infection (and not just disease) is because it will help determine whether or not vaccinated people can still transmit the virus — even if they're not sick.
"Ultimately, the best kind of vaccines are the ones that stop infection from being able to establish a foothold at all," Dr Labzin said, "so if we get exposed and we're vaccinated, we're not going to accidentally transmit that onto someone who's not vaccinated."
Dr Quinn said the mechanism used in the experimental vaccines to prevent disease "should also hopefully be reducing viral load in people" and therefore reduce their likelihood of shedding the virus and infecting someone else.
"But it's really hard to say at this point whether either of these vaccines are impacting infection rates … and how they're impacting the likelihood of someone who is vaccinated [passing] the infection onto other people."
That all depends on viral load and how much viral replication is happening, Dr Quinn said.
'They do have ways of looking at that, but that kind of information won't come until later."
Dr Quinn said there are examples of other vaccines where people can be vaccinated, but still spread a disease to others.
Yes, very wield results if you listen to the U-tube above. It makes me realize that mixing vendor products is a going to be a huge unknown. What happens if you start down a vendor path and then can't get the second shot (much like we saw with Shingles shots)? How long do you wait before you switch to another vendor product? Hopefully we will get some guidance on this issue as we move forward.Weird results with the AstraZeneca with 1/2 dose / full dose. So far, I haven't heard why it was weird.
Yes i think I will continue to wear a mask on public transit and other crowds.It just takes a little discipline and could reap outsized rewards.in an at-risk group, I'd recommend maintaining common-sense protocols until both are true:
The community/stores no longer requires/recommends masks
and
The R0 rate in the areas I'm going to be are super low (like way sub sub 1%)
Even then, with things like flying? I might keep up a mask for a long time. I got a cold or something, way more than 25% of the times I flew in the past.
Yes, very wield results if you listen to the U-tube above. It makes me realize that mixing vendor products is a going to be a huge unknown. What happens if you start down a vendor path and then can't get the second shot (much like we saw with Shingles shots)? How long do you wait before you switch to another vendor product? Hopefully we will get some guidance on this issue as we move forward.