It’s hard to stop Alzheimer’s?

[RetMD21]

There are hundreds (at least) of associations but people like picking specific nutrients to track. A better diet can't hurt but is probably harder to do day after day. Exercise is important but probably underemphasized. Hearing impairment, social isolation, air pollution, diabetes avoidance, bp control, weight, alcohol, smoking, social isolation, and sleep are or may be important. Here is another link to the 2020 Lancet report by actual experts who aren't selling anything: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392084/

 

[Koolau]

There are hundreds (at least) of associations but people like picking specific nutrients to track. A better diet can't hurt but is probably harder to do day after day. Exercise is important but probably underemphasized. Hearing impairment, social isolation, air pollution, diabetes avoidance, bp control, weight, alcohol, smoking, social isolation, and sleep are or may be important. Here is another link to the 2020 Lancet report by actual experts who aren't selling anything: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392084/

Thanks for the document. I downloaded the pdf but will need some time to look through it.

It sound like you "agree" (can't think of a better way to say it) with me that "it's complicated." Picking a few things to emphasize may be a fools errand. Absolutely, maintaining "good health" is probably "protective" but guarantees nothing (but, well, better "health.")

I'm frustrated. I became interested in Alzheimers when my dad was a victim beginning almost 40 years ago (heh, heh, roughly my age now) From the document, is there any more "hope" for prevention or treatment or cure?

Thanks again and aloha.

 

[daylatedollarshort]

There are hundreds (at least) of associations but people like picking specific nutrients to track. A better diet can't hurt but is probably harder to do day after day. Exercise is important but probably underemphasized. Hearing impairment, social isolation, air pollution, diabetes avoidance, bp control, weight, alcohol, smoking, social isolation, and sleep are or may be important. Here is another link to the 2020 Lancet report by actual experts who aren't selling anything: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392084/

We're tracking every nutrient we can test for. That is actually the whole point of what we are doing - testing nutrients, organic acids and our microbiomes. Many of the items in that list are high level disorders, which in turn are also linked to a wide variety of nutrient deficiencies as well as microbiome issues. Here are just a few -

Association of Nutritional Factors with Hearing Loss - PubMed (nih.gov) - "These studies found that the incidence of HL was increased with the lack of single micro-nutrients such as vitamins A, B, C, D and E, and zinc, magnesium, selenium, iron and iodine. Higher carbohydrate, fat, and cholesterol intake, or lower protein intake, by individuals corresponded to poorer hearing status."

Understanding nutrition, depression and mental illnesses - "The dietary intake pattern of the general population in many Asian and American countries reflects that they are often deficient in many nutrients, especially essential vitamins, minerals, and omega-3 fatty acids.[3] A notable feature of the diets of patients suffering from mental disorders is the severity of deficiency in these nutrients.[3] Studies have indicated that daily supplements of vital nutrients are often effective in reducing patients' symptoms.[4] Supplements containing amino acids have also been found to reduce symptoms, as they are converted to neurotransmitters which in turn alleviate depression and other mental health problems.[4] On the basis of accumulating scientific evidence, an effective therapeutic intervention is emerging, namely nutritional supplement/treatment."

The Malnutrition of Obesity: Micronutrient Deficiencies That Promote Diabetes - "As with nearly all biochemical processes, glucose metabolism and insulin signaling require cofactors and vitamins that are essential in the diet. Deficiencies in any of these micronutrients have potential to impair glucose metabolism and cause insulin resistance. Clinical evidence supporting this hypothesis regarding the metabolic effects of specific deficiencies including vitamin D, chromium, biotin, thiamine and vitamin C is mounting. Unlike vitamin E, which has little to no proven clinical effect when given as a supplement, these vitamins are known to be deficient at relatively high rates in obese individuals and in diabetic patients. Clinicians should consider addressing possible deficiencies of these micronutrients when advising obese patients who are at risk for the development of type 2 diabetes."

A healthy diet for one person might not be healthy for another person. High in oxalates? FODMAP sensitive? High in phenols? Salycilate sensitive? Celiac disease? High in uric acid or low in uric acid promoting foods? Which is better? You usually don't know unless you test, but the tests we are doing can identify many of these issues. These new gut and organic acid tests are quite amazing. The labs keep improving them all the time as more and more research accumulates, especially on cornerstone gut bacteria. I have been able to correct my gut and allergy issues from the tests. I found a video explaining how this happened and posted it in the current allergy thread.

 

[Letj]

We're tracking every nutrient we can test for. That is actually the whole point of what we are doing - testing nutrients, organic acids and our microbiomes. Many of the items in that list are high level disorders, which in turn are also linked to a wide variety of nutrient deficiencies as well as microbiome issues. Here are just a few -

Association of Nutritional Factors with Hearing Loss - PubMed (nih.gov) - "These studies found that the incidence of HL was increased with the lack of single micro-nutrients such as vitamins A, B, C, D and E, and zinc, magnesium, selenium, iron and iodine. Higher carbohydrate, fat, and cholesterol intake, or lower protein intake, by individuals corresponded to poorer hearing status."

Understanding nutrition, depression and mental illnesses - "The dietary intake pattern of the general population in many Asian and American countries reflects that they are often deficient in many nutrients, especially essential vitamins, minerals, and omega-3 fatty acids.[3] A notable feature of the diets of patients suffering from mental disorders is the severity of deficiency in these nutrients.[3] Studies have indicated that daily supplements of vital nutrients are often effective in reducing patients' symptoms.[4] Supplements containing amino acids have also been found to reduce symptoms, as they are converted to neurotransmitters which in turn alleviate depression and other mental health problems.[4] On the basis of accumulating scientific evidence, an effective therapeutic intervention is emerging, namely nutritional supplement/treatment."

The Malnutrition of Obesity: Micronutrient Deficiencies That Promote Diabetes - "As with nearly all biochemical processes, glucose metabolism and insulin signaling require cofactors and vitamins that are essential in the diet. Deficiencies in any of these micronutrients have potential to impair glucose metabolism and cause insulin resistance. Clinical evidence supporting this hypothesis regarding the metabolic effects of specific deficiencies including vitamin D, chromium, biotin, thiamine and vitamin C is mounting. Unlike vitamin E, which has little to no proven clinical effect when given as a supplement, these vitamins are known to be deficient at relatively high rates in obese individuals and in diabetic patients. Clinicians should consider addressing possible deficiencies of these micronutrients when advising obese patients who are at risk for the development of type 2 diabetes."

A healthy diet for one person might not be healthy for another person. High in oxalates? FODMAP sensitive? High in phenols? Salycilate sensitive? Celiac disease? High in uric acid or low in uric acid promoting foods? Which is better? You usually don't know unless you test, but the tests we are doing can identify many of these issues. These new gut and organic acid tests are quite amazing. The labs keep improving them all the time as more and more research accumulates, especially on cornerstone gut bacteria. I have been able to correct my gut and allergy issues from the tests. I found a video explaining how this happened and posted it in the current allergy thread.

Thank you!! Really appreciate all health and wellness information you share with us.

 

[daylatedollarshort]

Thank you!! Really appreciate all health and wellness information you share with us.

Just trying to share my good fortune in stumbling across these tests. The results have been almost too good to be true. But like the allergy video in the other thread shows, there is solid science behind the test results and improvements.

 

[Letj]

Really liked the video you shared in the other thread. If your tests reveal you have certain bacteria (non-beneficial), is there really anything you can do to correct that or is it just for information purposes?

 

[daylatedollarshort]

Really liked the video you shared in the other thread. If your tests reveal you have certain bacteria (non-beneficial), is there really anything you can do to correct that or is it just for information purposes?

Based on our experience, there is a lot you can do. I had over 30 markers off between the two tests and am optimistic I can clear many, maybe all, of them. I know I've cleared up a few already because I've been using the Quest lab blood tests to checkpoint a few of the key biomarkers. Some of us in my family are starting to rerun the initial tests to see what is left to clear up. I won't know about most of the gut bacteria until I run GI Map again, but based on my gut and allergy issues clearing up that is a good sign. The GI Map has an interpretive guide that usually has some suggestions for most of the out of range markers / bacteria. There are many videos online with case studies and treatment plans by the labs and the doctors who use the tests. Plus, in general, once you know what exactly what you have wrong, you can Google that particular bacteria or marker for more information, or hire someone with expertise in the tests to help with interpretation and a treatment plan.

 

[DrRoy]

That seems pretty "hard" to believe.

 

[Letj]

Based on our experience, there is a lot you can do. I had over 30 markers off between the two tests and am optimistic I can clear many, maybe all, of them. I know I've cleared up a few already because I've been using the Quest lab blood tests to checkpoint a few of the key biomarkers. Some of us in my family are starting to rerun the initial tests to see what is left to clear up. I won't know about most of the gut bacteria until I run GI Map again, but based on my gut and allergy issues clearing up that is a good sign. The GI Map has an interpretive guide that usually has some suggestions for most of the out of range markers / bacteria. There are many videos online with case studies and treatment plans by the labs and the doctors who use the tests. Plus, in general, once you know what exactly what you have wrong, you can Google that particular bacteria or marker for more information, or hire someone with expertise in the tests to help with interpretation and a treatment plan.

I think the tests would help me and maybe confirm some of what I’ve been noticing on my own. My conventional labs work don’t really show anything out of range yet I have certain symptoms with no explanation (just idiopathic they keep saying). I know the body is smart and I don’t believe there’s no explanation for symptoms.

 

[Jenna]

Vitamin B1 as a potential treatment for Alzheimer’s Disease (AD) Vitamin B1 as a potential treatment for Alzheimer’s Disease (AD) – To Extract Knowledge from Matter Georgi Dinkov and Ray Peat have excellent critics on current studies about AD

 

[daylatedollarshort]

Vitamin B1 as a potential treatment for Alzheimer’s Disease (AD) Vitamin B1 as a potential treatment for Alzheimer’s Disease (AD) – To Extract Knowledge from Matter Georgi Dinkov and Ray Peat have excellent critics on current studies about AD

My family member with the brain disorder was deficient in vitamin B1. They also had over 20 other out of range issues, many commonly linked to Alzhemier's and other brain disorders, including a number of gut issues. They were also fine in many other markers linked to their diagnosed disorder in the research. Without the testing, we would have had no way of knowing what to treat.

Another clue that the gut is involved in AD, at least in mouse models of the disease: Fecal implants drive behavioral and cognitive changes in Alzheimer’s model - https://news.ohsu.edu/2022/02/08/fe...ral-and-cognitive-changes-in-alzheimers-model

 

[Koolau]

Vitamin B1 as a potential treatment for Alzheimer’s Disease (AD) Vitamin B1 as a potential treatment for Alzheimer’s Disease (AD) – To Extract Knowledge from Matter Georgi Dinkov and Ray Peat have excellent critics on current studies about AD

The reason I (we?) grasp at info such as this (and the info on Viagra) is that it's a simple (take a pill) solution to a devastating illness. I keep thinking one of these "treatments" announced over that past 20 years will actually work. I hope so as I'm only getting older. YMMV

 

[daylatedollarshort]

The reason I (we?) grasp at info such as this (and the info on Viagra) is that it's a simple (take a pill) solution to a devastating illness. I keep thinking one of these "treatments" announced over that past 20 years will actually work. I hope so as I'm only getting older. YMMV

What if it is a multifactorial disorder for many people, for example 5% vitamin B1 deficiency, 7.5% vitamin D deficiency, 3% leaky gut, 2% pesticide exposure, 8% fungal infections, etc.? And maybe different people have different contributing causes. Is there one cause to heart disease?

 

[Winemaker]

I can't help myself into thinking having a certain skill set also helps with AD or dementia. While I haven't personally given them a physical, how is it that some rock and rollers (although they've done stupid things in their life) still seem to carry on. Keith Richards, Rod Stewart, Paul McCartney, Stephen Tyler to name a few. Abused alcohol, drugs etc, but are still touring.

 

[Time2]

This video with Dr. Paul Mason,

Discusses the link between sugar and seed oils (that oxidize even before we buy them), and beta amyloids. Also APOE4 can have 5 times increase in Alzheimers, but, a diet low in sugar and seed oils i.e, not having metabolic syndrome removes that risk. This leads to a ketogenic diet high in Lard and butter, and not olive oil and seed oils. If that offends you don't watch.
Writing as I have ketone level of 5.2 and glucose of 91.

 

[daylatedollarshort]

There is another famous study - Two-Week International Diet Swap Shows Potential Effects of Diet on Colon Cancer Risk – African-Americans and Africans who swapped their typical diets for just two weeks similarly exchanged their respective risks of colon cancer as reflected by alterations of their gut bacteria, according to an international study led by researchers at the University of Pittsburgh School of Medicine published online today in Nature Communications.

The African diet in this study was not a keto diet, but it was a high fiber diet of whole foods, and not processed foods. We decided in my family after looking at everybody's test results, there is really no one size fits all diet, though modern, processed foods and pesticide laden foods aren't probably good for most people. None of us are on keto diets and no one has elevated glucose or A1C markers, but we had a lot of other things off when looking at 100+ markers for each person. Research shows there is a lot more to overall good health than just common lab markers like A1C and cholesterol.

 

[misanman]

the link between sugar and seed oils (that oxidize even before we buy them), and beta amyloids

Friend of mine says his wife was cured of Alzheimers when she eliminated sugar from her diet.

 

[audreyh1]

Friend of mine says his wife was cured of Alzheimers when she eliminated sugar from her diet.

Personally, barring poisoning or head trauma, I believe good metabolic health is powerful protection against dementia including Alzheimer’s. So eliminating sugar and processed starchy carbs from is a very good approach as that allows reversal of metabolic disease.

 

[Koolau]

What if it is a multifactorial disorder for many people, for example 5% vitamin B1 deficiency, 7.5% vitamin D deficiency, 3% leaky gut, 2% pesticide exposure, 8% fungal infections, etc.? And maybe different people have different contributing causes. Is there one cause to heart disease?

Agreed. But, for instance, with all those causes for heart disease, sometimes a stent is all that's needed to "fix" the issue. Never ideal to fix something rather than prevent it, but a fix sure is great if one fails to prevent.

There may well be lots of "causes" to AD. But, just possibly, one treatment could alleviate the main symptom that manifests as AD. Realistically, that's the only thing a drug company could address. No idea if such a "cure" could be found, but it sure would be nice - and I'd pay a lot for it (if needed.)