I've been here in the greater Cincinnati area for nearly 30 years. Before that I lived all over the the country and practically all over the world, so I have always been able to adjust rapidly to new environments.
DW, OTOH, has lived in this area all her life and has a zillion friends and acquaintances that she stays close to. She simply can't imagine ever living anywhere else, although she loves to travel as well.
We have a low cost of living here, practically every amenity anyone could want, and a decent climate. I've often heard it said that we're within a day's drive of 60% of the US/Canada population so that makes us pretty centrally located.