anethum
Full time employment: Posting here.
- Joined
- May 26, 2012
- Messages
- 856
In the Novavax phase 2B trial in South Africa, efficacy was much lower than in the phase 3 trial in the UK.NOPE! But waiting for the Best vaccine on this planet - Novavax with 96% efficacy on the original strain and 86% on the UK strain. Also the safest vaccine as it is protein based.
I won't even bother with Astra and JNJ vaccines - these are one-shot vaccines. Covid will be endemic like the flu, and you'll most likely need yearly vaccination. These vaccines will be ineffective the 2nd year, as they are all 'adenovirus vector vaccines'.
"The experience with adenoviruses has been for many years that vectors can be intercepted by the immune system after repeat injections," said Bodo Plachter, deputy director of the Institute of Virology at Mainz University's teaching hospital.
That leaves Novavax, Pfizer, and Moderna. However, Pfizer and Moderna are mRNA vaccines, and they viewed by your immune system as foreign and will attack it to build your immunity, so Pfizer and Moderna have more adverse side effects - high fever, etc. Novavax, a protein based vaccine, is the safest and has the least side effects as they already create the spike protein, using nano-particles, to train the system to build immunity.
https://www.yahoo.com/news/astrazeneca-sputnik-vaccines-face-hurdles-080912966.html
https://ir.novavax.com/news-release...-vaccine-demonstrates-893-efficacy-uk-phase-3
"In the South Africa Phase 2b clinical trial, 60% efficacy (95% CI: 19.9 – 80.1) for the prevention of mild, moderate and severe COVID-19 disease was observed in the 94% of the study population that was HIV-negative. Twenty-nine cases were observed in the placebo group and 15 in the vaccine group. One severe case occurred in the placebo group and all other cases were mild or moderate. The clinical trial also achieved its primary efficacy endpoint in the overall trial population, including HIV-positive and HIV-negative subjects (efficacy of 49.4%; 95% CI: 6.1 – 72.8)."
90% of the covid-19 cases in the South Africa trial were attributed to the South African variant of the virus.
There is another factor which isn't being discussed in terms of possible side effects from the Novavax vaccine. That is the "Matrix M" saponin adjuvant used in that vaccine. The Shingrix vaccine also contains a saponin adjuvant. As far as I have been able to determine, both saponin adjuvant compounds are derived from the same South American plant, Quillaja saponaria. I haven't been able to determine if the two adjuvants are identical, however. The Shingrix adjuvant is believed to be the reason the side effects of the Shingrix vaccine tend to be worse than from other vaccines. I had a severe reaction to my one and only dose of the Shingrix vaccine (complete deafness in one ear, fortunately reversed with very prompt treatment. However I now have permanent tinnitus in that ear.) The Novavax vaccine is one covid vaccine which I will avoid. Anyway, I've already received my first dose of the Pfizer vaccine. My only reaction was mild arm soreness which lasted less than 24 hours, which is the same reaction I get from my annual flu shot.
- - - - - - - - - -
And why do you say a protein-based vaccine is safer?