I grew up in the north part of PA, about an hour northeast of Scranton. I still go back and visit family, and the single best advice I can give is rent first.
Depending how far you move from a larger city (HCOL), some of the things you might (I definitely do!) consider essential are lacking. For example, very poor/no broadband. Parents and family have never streamed anything. Never had any food delivered.... Just a different way of life. All that being said, a dollar goes a long way. Some high school friends are still making $35-$40k and seem to be happy. Definitely some backwards things in PA though. No wine or beer sold in stores is a hard one for me to get used to.
As you head south through Bucks county cost start inching up, but the amenities start to tick up as well. For me its a great place to visit and glad I grew up there, but if I was to retire there I'd try to be close to some of the bigger cities (Harrisburg, Allentown, Bethlehem, etc.).