2 yrs ago, a urologist in the town where I work (4 days a week, have an apt.) did the DRE and told me the same thing. He said he wanted to do a biopsy. I googled the procedure on the net & didn't like what I read about it, sounded like the biopsy can cause problems of it's own. So...I made an appointment for a 2nd opinion in my "other" town (where my wife lives in Louisiana & I go to on weekends), with a urologist I'd had previous experience with (kidney stones). Doc number 2 did a DRE and asked me if I was sure the 1st Doc was really a urologist (half joking). He said he felt absolutely nothing unusual, however, to be safe, requested I come see him again in 6 months so he could check again. I was a little slow to get back, and it was closer to a year later, but I did finally go back for another check-up. This time, the results were the same....nothing...nada. Also, I found out I have a low PSA reading....I believe it was .071 or so. Anyhow, I'm certainly glad I didn't just jump onto the biopsy bandwagon before the 2nd opinion. Most likely, I'd have gotten a 3rd opinion before getting the biopsy. I understand how dangerous this stuff is, and I wouldn't have played around if test #2 had agreed with test #1, but I'm saying I'm a believer in multiple opinions for this kind of thing. I wish you the best...