I want my antibiotics!

[Brat]

I agree phages may be a solution BUT they must be carefully matched to the specific bacteria causing the problem. This is not a situation where a phage cocktail can be used to treat a class of infections.

 

[REWahoo]

I heard about this use of phages yesterday. Exciting and encouraging, but a long way to go before becoming mainstream.

 

[Alan]

This is not a situation where a phage cocktail can be used to treat a class of infections.

Not yet but many journeys start with a few small steps.

 

[bjorn2bwild]

Another promising approach to resistance are antibiotics based on bacteriocins to narrow the spectrum.

Until last month I was still pessimistic about our chances of avoiding the antibiotics nightmare. But that changed when I attended a workshop in Beijing on a new approach to antibiotic development based on bacteriocins – protein antibiotics produced by bacteria to kill closely related species, and exquisitely narrow-spectrum.

If you consider a killing domain as a red Lego brick and a targeting domain as a yellow Lego brick, you can make hundreds of different hybrid proteins consisting of one red and one yellow brick to make what I refer to as a series of novel bacteriocin-derived antibiotics (BDAs). In fact, several BDAs have already been designed to kill target bacteria, fungi and even tumour cells.

https://www.theguardian.com/comment...lypse-research-resistance-threat-breakthrough


Download for full text ----


https://www.researchgate.net/publication/309922976_BACTERIOCIN_AN_ALTERNATIVE_TO_ANTIBIOTICS

 

[joeea]

Maybe phages will be the answer.

https://www.theguardian.com/science...rst-gm-virus-treatment?CMP=Share_iOSApp_Other

“Teenager recovers from near death in world-first GM virus treatment
Bacteria-killing viruses known as phages offer hope of solution to antibiotic resistance”

Wait, aren't GMOs a bad thing?

 

[bjorn2bwild]

This is not a situation where a phage cocktail can be used to treat a class of infections.

Not yet but many journeys start with a few small steps.

In this case they are using phage cocktail to describe the therapy ----

An experimental cocktail of viruses has saved the life of a teenager who had a deadly and seemingly untreatable infection.
Isabelle's body was being attacked by bacteria and she was given less than a 1% chance of survival.
But doctors at Great Ormond Street Hospital attempted an untested "phage therapy", which uses viruses to infect and kill bacteria.
Isabelle is now learning to drive and studying for her A-levels.
Experts said the case was "enormously exciting" and showed the potential for treating other dangerous infections with phage.

https://www.bbc.com/news/health-48199915

 

[spncity]

Full disclosure: I sit on a NIH-sponsored scientific working group on infectious diseases. In my former job, almost every major pharmaceutical company was a client.

Anything new these days on Lyme disease?