We have lived in 2 opposing climates from 2011-15 with mini splits, CA and Mexico (Caribbean). I would not hesitate putting them in any home personally.
Plusses are zone control, saving electricity, very efficient due to no duct loss of energy & super easy installation (one hole in the exterior wall).
Negatives, maybe less efficient for humidity due to zone usage, but we never were uncomfortable in Mexico to my recollection. It definitely drained a bunch of water as it ran.
You shouldn't skimp on a 220v system that will run more efficiently. The 110v system is only for single room use, imo (think window unit).
Filters are super easy to clean too. No extra filters for sensitive noses that I know of, but again, no duct for collecting dust or pollen too. Also, think about the views of the line that will be used (exterior & 1 per unit). Multi units will have multi holes and lines. May not be clean looking on the outside.
They do run super quiet, so much so that you forget to turn them off...