It is certain that the mind-altering effects of drugs vary with the person. As mentioned, having seen what happened to my addicted relatives when I was still young, I had no desire to try anything other than alcohol and cigarettes. Not even MJ for me.
I did not even know about the craze happening out in the real world with Oxycontin and Oxycodone. When I went in for major surgeries a few times 8 years ago, I was given Oxycodone, and remembered reading in the news something about addiction to it. I did some research on the Web while still on a hospital bed, and was afraid I might get hooked like some did.
I tried to not take any, and the pain made me take some. I ended up using about 1/2 of the allowed dosage, and it did alleviate the pain. No euphoric effects or anything like that. So, I still wonder what it is all about, what could cause people to go crazy and do anything to get it. It's a mystery to me.