The young wife and I have no children, and it is likely that I will predecease her, so this all may be moot. But, if it were my choice alone, I think I would give all my money to my oldest nephew, who also has no children. To my thinking, there should always be one rich person in the family to follow in my footsteps and be the emergency funder of last resort when family members fall into difficulty (which they often do). If I give it to any of my nephews with children, they will split it up among those children and dissipate it. It is, of course, not legally enforceable at all, but I would suggest that my favored nephew also exercise similar discretion in growing and eventually passing it on. In my dreams, I see a long line of childless uncles working to grow the family fortune. Ultimately, my goal is that someone down the family line will have sufficient funds to make a real difference in this world.